Completed
RAJA FAISAL ZULFIQAR
ANATOMY
Dec 22, 2025
Objectives: To evaluate histopathological & physiological alterations in lenses affected by
senile cataracts for a better understanding of the disease.
Methodology: After approval from the relevant ethical committee, analysis of 20 lenses
removed surgically for Implant of a synthetic lens in patients aged 55 to 70 years was performed
by histopathologic techniques using hematoxylin & eosin-stained slides and anatomical
micrometric measurements. The duration of the study was approximately six (6) months.
Random probability sampling was used.
Results: 55% of the crystalline lenses were found to have pathologic calcification, 45% of
them showed enlarged or bladder cells, 40% presented with nuclear fibrosis, 20% had ectopic
shifting of surface lining epithelial cells underneath the posterior capsule, and finger-like
microstructures were seen projecting in the posterior wall of the capsule of the lenses in 15%
of lenses.
Conclusion: Most of the lenses attributed more than one histopathological finding. A marked
decrease in the size of epithelial cells was observed, whereas alterations in the thickness of the
lenses were insignificant with a p-value of >0.05. Al-Shifa Journal of Ophthalmology 2024;
20(1): 21-26. © Al-Shifa Trust Eye Hospital, Rawalpindi, Pakistan